Laboratoire d'Hématologie
et Consultations d'Hématologie Biologique
Pôle Biologie Pathologie

Equipe d'Accueil Universitaire EA 2992 "Dynamique des incohérences cardiovasculaires"

Les thématiques de Recherche

• Hémostase / thrombose / biologie du vaisseau
• Risque vasculaire
• Dysfonctions de l'interface hémo-placentaire

Hémostase et grossesse

• Facteurs de risque d'échecs de grossesse, de perte embryonnaire ou de mort fœtale inexpliquée, de complications vasculo-placentaires (pré-éclampsie,…)
• Anticorps anti phospholipides / cofacteurs protéiques
• Facteurs de risque de la maladie thromboembolique veineuse durant la grossesse

Les principales publications

• Gris JC, Bouvier S, Molinari N, Galanaud J.P., Cochery-Nouvellon E, Mercier E, Fabbro-Peray P, Balducchi J.P., Marès P, Quéré I, Dauzat M. Comparative incidence of a first thrombotic event in purely obstetric antiphospholipid syndrome with pregnancy loss: the NOH-APS observational study. Blood 2012; 119: 2624-32.
• Gris JC, C. Chauleur, N. Molinari, P. Marès, P. Fabbro-Peray, I. Quéré, J.Y. Lefrant, B. Haddad, M. Dauzat. Addition of enoxaparin to aspirin for the secondary prevention of placental vascular complications in women with severe pre-eclampsia: the pilot randomised controlled NOH-PE trial. Thrombosis and Haemostasis 2011; 106: 1053-61.
• Gris JC, Chauleur C, Faillie JL, Baer G, Marès P, Fabbro-Peray P, Quere I, Lefrant JY, Haddad B, Dauzat M. Enoxaparin for the secondary prevention of placental vascular complications in women with abruptio placentae. The pilot randomised controlled NOH-AP trial. Thrombosis and Haemostasis 2010 ; 104: 771-9.
• Chauleur C, Galanaud JP, Alonso S, Cochery-nouvellon E, Balducchi JP, Marès P, Fabbro-Peray P, Gris JC. Observational study of pregnant women with a previous spontaneous abortion before the 10th gestation week with and without antiphospholipid antibodies. Journal of Thrombosis and Haemostasis 2010; 8: 699-706.
• Galanaud JP, Cochery-Nouvellon E, Alonso S, Chauleur C, Mercier E, Lissalde-Lavigne G, Fabbro-Peray P, Reny JL, Mares P, Dauzar M, Quéré I, Gris JC. Paternal endothelial protein C receptor 219Gly variant as a mild and limited risk factor for deep-vein thrombosis during pregnancy. Journal of Thrombosis and Haemostasis 2010; 8: 707-13.
• Cochery-Nouvellon E, Chauleur C, Demattei C, Mercier E, Fabbro-Peray P, Marès P, Mismetti P, Lissalde-Lavigne G, Gris JC. The A6936G polymorphism of the endothelial protein C receptor gene is associated with the risk of unexplained foetal loss in Mediterranean European couples. Thrombosis and Haemostasis 2009; 102: 656-67.
• Chauleur C, Cochery-Nouvellon E, Mercier E, Aya G, Fabbro-Peray P, Patrick Mismetti P, Géraldine Lissade-Lavigne G, Gris JC. Some haemostasis variables at the end of the population distributions are risk factors for severe postpartum haemorrhages. Journal of Thrombosis and Haemostasis 2008; 12: 2067-74.
• Lissalde-Lavigne G, Combescure C, Muller L, Bengler C, Raillard A, Lefrant JY, Gris JC. Simple coagulation tests improve survival prediction in patients with septic shock. Journal of Thrombosis and Haemostasis 2008; 6: 645-53.
• Mercier E, Lissalde-Lavigne G, Gris JC. JAK2 V617F mutation in unexplained loss of first pregnancy. New England Journal of Medicine 2007; 357: 1984-5.
• Lissalde-Lavigne G, Fabbro-Peray P, Cochery-Nouvellon E, Mercier E, Ripart-Neveu S, Balducchi JP, Daures JP, Perneger T, Quere I, Dauzat M, Mares P, Gris JC. Factor V Leiden and prothrombin G20210A polymorphisms as risk factors for miscarriage during a first intended pregnancy: the matched case-control 'NOHA first' study. Journal of Thrombosis and Haemostasis 2005; 3: 2178-84.
• JC Gris, TV Perneger, I Quéré, E Mercier, P Fabbro-Peray, G Lavigne-Lissalde, M Hoffet, H Déchaud, JC Boyer, S Ripart-Neveu, ML Tailland, JP Daurès, P Marès, M Dauzat. Antiphospholipid / antiprotein antibodies, hemostasis-related autoantibodies and plasma homocysteine as risk factors for a first early pregnancy loss: a matched case-control study. Blood 2003; 102: 3504-13.
• JC Gris, C Amadio, E Mercier, G Lavigne-Lissalde, H Déchaud, M Hoffet, I Quéré, J Amiral, M Dauzat, P Marès. Anti-protein Z antibodies in women with pathologic pregnancies. Blood 2003; 101: 4850-2.
• JC Gris, E Mercier, I Quéré, M Dauzat. Association between the methylenetetrahydrofolate reductase C677T polymorphism and the risk of secondary lymphoproliferative disease in patients with a first idiopathic thrombosis. Blood 2002; 100: 735.
• JC Gris, I Quéré, H Dechaud, E Mercier, C Pinçon, M Vasse, P Marès. High frequency of protein Z deficiency in patients with unexplained early foetal loss. Blood 2002; 99: 2606-8.

Les contrats de recherche

• Risque thrombotique, grossesse et pronostic fœtal. Divers contrats d'entreprise
• Insuffisance rénale chronique dialysée et risque vasculaire. Extra Mural Grant, Baxter.
• Développement et validation de nouveaux coffrets diagnostics appliqués à la pathologie de l'hémostase. Partenariats universitaires avecla société Biopep/ ABX, Mauguio; STAGO, Asnières.
• PHRC nationaux, inter-régionaux, projets de recherche GCS-MERRI Nîmes-Montpellier, projets locaux.